This Phenoconversion Pharmacogenetics Calculator is intended to help clinicians integrate a standardized method of assessing CYP2D6 phenoconversion into practice when a CYP2D6 genotype is available. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion.
Use this calculator to enter a patient’s CYP2D6 genotype and choose any interacting medications and the patient’s activity score and clinical phenotype will be displayed. This calculator is consistent with how UF Health translates CYP2D6 genotype to phenotype. For a calculator that uses the most updated recommendations for translating CYP2D6 genotype to phenotype by Clinical Pharmacogenetics Implementation Consortium (CPIC) please use PROP™.